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Both medications had similar gastrointestinal side effects

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Rather than conducting a new meta-analysis, the authors synthesize findings from major randomized clinical trials, highlighting outcomes related to glycated hemoglobin (HbA1c), body weight reduction, major adverse cardiovascular events (MACE), and kidney function decline as reported in large cardiovascular outcomes trials (CVOTs), obesity randomized controlled trials, and early-phase clinical development studies

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Prospective trial needed, but this result is pretty striking

DSIP is studied for its interaction with neuroendocrine regulatory systems within the central nervous system